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One of the challenges in assessing hydroxychloroquine's effectiveness against COVID-19 is the lack of large-scale, well-designed clinical trials. [url=https://hydroquin.com]plaquenil for lupus[/url] Many early studies were small, observational, or retrospective in nature, making it difficult to draw definitive conclusions about its efficacy. Robust, randomized controlled trials are needed to provide high-quality evidence regarding hydroxychloroquine's role in managing COVID-19.